MI DNA Day module list:
- DNA Damage and Cancer
- Genomics and Inheritance
- Microbiology and Immunology
DNA Damage and Cancer
Students will learn how DNA mutations can lead to cancer, specifically focusing on the inheritance of the BRCA1 gene and its contribution to breast cancer. Students will analyze DNA sequences and compare the affect of different mutations on the resulting protein sequence. Students will also consider other ways DNA mutations can be introduced with a focus on UV light. For longer or more advanced classes, students will also discuss ways our cells repair DNA damage and how this has informed cancer treatments.
Students will learn how forensic scientists analyze DNA in order to link a DNA sample to a particular individual. Students will learn about powerful molecular biology techniques such as PCR, restriction digests, and gel electrophoresis. To learn more about DNA and how it is used by forensic scientists, students will isolate DNA from their own saliva! Using their newfound understanding of DNA and forensics techniques, students will help solve an interactive “Whodunit?” case.
GENOMICS AND INHERITANCE
Students will learn the ins and outs of the human genome – what makes us each unique and how traits are inherited. Hands on activities include DNA isolation from their own saliva and completing a Punnet square to determine inheritance in flowers. For longer or more advanced classes, students will learn how Genome Wide Association Studies (GWAS) help identify genes responsible for complex human disease.
Students will learn about the concept of “personalized” medicine, like how differences in our genes affect whether a drug treatment will be successful or have serious side effects, and how we can use this information to customize treatments for individual patients. Students will participate in a hands-on activity to further demonstrate how subtle differences affect a patient’s response to medication.
MICROBIOLOGY AND IMMUNOLOGY
Students will learn basic concepts in microbiology and immunology, including the difference between bacteria and viruses, and why treatments (such as antibiotics) work on one type of microbes, but not the other. Students will also learn about the immune system and be able to explain how vaccines work. Hands-on activities include an exercise to demonstrate how antibiotic resistance evolves. Extended topics for longer or advanced classes include cancer immunology, neuroinflammation, epidemiology, and microbes in the environment.
Students will learn about epigenetics, or how the features of a person (phenotype) might be different even if their genome (genotype) is identical. Students will be presented with both mechanisms and real-world examples of epigenetics. Hands-on activities include following a set of twins through various life decisions and seeing how their phenotypes might differ from each other over time.
OUR MODULE TEAM
Thanks to the graduate students, postdocs, and faculty who helped design the MI DNA Day modules!
- Julie Philippe (Curriculum leader)
- Andrea Pesch (Curriculum leader)
- Katherine Bonefas (special thanks for contribution to 2 modules)
- Catherine Barnier
- Amanda Moccia
- Kate Van Pelt
- Rahasudha Kannan
- Alexander Monovich
- Lucas Huffman
- Haley Brown
- Samantha Kemp
- Leigh Baker
- Sandra Carson
- Muyu Situ
Interested in designing a new module?
We are very interested in expanding our list of possible modules. If you have an idea, let us know! We can work with you to build an engaging and interactive module for an upcoming DNA Day.
Contact us here or by emailing us at firstname.lastname@example.org